The term Entourage Effect was first used in cannabinoid science by S. Ben-Shabat and noted cannabis researcher Raphael Mechoulam  in 1998.

It is the biological interaction of cannabinoids and other compounds like flavonoids and terpenes. When terpenes and flavonoids work with cannabinoids like CBD, the synergy creates stronger and richer effects than either would achieve on their own. So it isn’t just the cannabinoids that help create this entourage effect. Terpenes such as limonene, myrcene, pinene, humulene, linalool, beta-caryophyllene, and flavinoids also lend their beneficial properties to the overall impact that ingesting cannabinoids can have.

CBD Oil extracted from the Whole Plant contains many cannabinoids, flavonoids, and terpenes, as well as essential vitamins and minerals, fatty acids, fibre and protein, to encourage the Entourage Effect.  

At Canaxen we source 100% organic, pesticide free, CBD strains from across Europe and bring them back to our UK Laboratory, where we manufacture our oils to the highest level of quality control. How Canaxen Make CBD Oil

All our products are created from whole plant extraction, to ensure they contain natural Terpenes and Flavonoids to enhance the Entourage Effect.

Every batch of oil is tested by an independent laboratory to ensure each product contains the amount of CBD advertised.  See our Laboratory Results

We are here to answer any of your questions about the Canaxen range. For customer service and advice, get in touch with our team.  Contact us


From Wikipedia, the free encyclopedia
 The term entourage effect refers to a concept and proposed mechanism by which compounds present in cannabis which are largely non-psychoactive by themselves modulate the overall psychoactive effects of the plant.

Cannabidiol (CBD) is believed to be the major modulatory component of cannabis, mitigating some of the negative, psychosis-like effects of THC, and is included in some medicinal formulations alongside THC.

CBD co-administration also reduces the negative effects of THC on memory. Myrcene, which is recognized as a sedative component in hops, may be responsible for the sedative effects (“couch lock”) of certain cannabis strains (sedative effects are commonly ascribed to the indica cannabis type). Linalool may also contribute to the entourage effect, modulating the glutamate and GABA neurotransmitter systems to produce sedative and anxiolytic effects.

Though the idea of the entourage effect has taken root in the cannabis industry and among consumers, the concept is often based on conjecture and anecdotal evidence as rigorous scientific underpinning is lacking.

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